Which of the following animals is ammonotelic?
(a) Birds
(b) Mammals
(c) Bony fishes
(d) Land snails
The functional unit of the human kidney is:
(a) Neuron
(b) Nephron
(c) Malpighian tubule
(d) Protonephridia
Assertion (A): Ammonia is the most toxic nitrogenous waste and requires large amounts of water for its elimination.
Reason (R): Uric acid is the least toxic nitrogenous waste and can be removed with minimum loss of water.
(a) Both A and R are true and R is the correct explanation of A.
(b) Both A and R are true but R is not the correct explanation of A.
(c) A is true but R is false.
(d) A is false but R is true.
The glomerular filtration rate (GFR) in a healthy adult human is approximately:
(a) 125 ml/min
(b) 180 ml/min
(c) 1.5 litres/min
(d) 1200 ml/min
Assertion (A): The ascending limb of the loop of Henle is impermeable to water but allows transport of electrolytes.
Reason (R): This helps in maintaining the high osmolarity of the medullary interstitial fluid.
(a) Both A and R are true and R is the correct explanation of A.
(b) Both A and R are true but R is not the correct explanation of A.
(c) A is true but R is false.
(d) A is false but R is true.
Which structure is absent or highly reduced in cortical nephrons?
(a) Bowman’s capsule
(b) Proximal convoluted tubule
(c) Vasa recta
(d) Collecting duct
The process of release of urine is called:
(a) Ultrafiltration
(b) Micturition
(c) Osmoregulation
(d) Counter current mechanism
Juxtaglomerular apparatus (JGA) is formed by modifications in:
(a) PCT and efferent arteriole
(b) DCT and afferent arteriole
(c) Loop of Henle and vasa recta
(d) Collecting duct and peritubular capillaries
Which of the following is not a nitrogenous waste excreted by humans?
(a) Urea
(b) Uric acid
(c) Ammonia
(d) Bilirubin
The counter current mechanism operates between:
(a) PCT and DCT
(b) Two limbs of Henle’s loop and two limbs of vasa recta
(c) Glomerulus and Bowman’s capsule
(d) Collecting duct and renal pelvis
Case 1: A patient shows symptoms of uremia due to kidney malfunction. Doctors recommend hemodialysis as a temporary measure.
(a) What is uremia?
(b) Explain the principle of hemodialysis.
(c) Why is heparin added during the process?
(d) Name the ultimate method for correction of acute renal failure.
Case 2: An adult human excretes about 1–1.5 litres of urine daily. The urine is light yellow, slightly acidic (pH 6.0) and contains 25–30 g of urea. Presence of glucose or ketone bodies indicates a metabolic disorder.
(a) What is the normal daily volume of urine in a healthy adult?
(b) Name the condition indicated by glucose in urine.
(c) State the role of collecting duct in urine concentration.
(d) How does analysis of urine help in clinical diagnosis?
Case 1: (a) Accumulation of urea in blood — 1 mark; (b) Blood passed through dialysing unit with semipermeable membrane — 1 mark; (c) Prevents clotting — 1 mark; (d) Kidney transplantation — 1 mark.
Case 2: (a) 1–1.5 litres — 1 mark; (b) Glycosuria (diabetes mellitus) — 1 mark; (c) Reabsorbs water, secretes H+/K+ — 1 mark; (d) Detects metabolic disorders like diabetes — 1 mark.
All questions are answerable from the NCERT chapter text. Reviewed by GFIS faculty.